Vayne, the Night Hunter, is one of the most powerful late-game ADCs in League of Legends (LoL). Her dueling potential, high mobility, and true damage make her a strong pick, especially when paired with the optimal runes and items. In this Vayne guide, we'll explore the best ADC build for Season 14, including her runes, items, and strategies.

Vayne ADC Build

When playing Vayne ADC, it's crucial to focus on attack speed, on-hit damage, and survivability to dominate in both teamfights and 1v1 skirmishes. The following builds are two of the most popular and successful setups:

Build 1: Blade of The Ruined King + Guinsoo's Rageblade + Terminus

This build focuses on maximizing Vayne’s true damage and survivability. It has a win rate of 62.56% across 8,815 games and is considered one of the best Vayne season 14 builds.

1. Blade of The Ruined King: Core item for Vayne, providing attack speed, life steal, and additional damage based on the enemy’s health.
2. Guinsoo's Rageblade: Converts critical strike chance into on-hit damage, allowing Vayne to proc her Silver Bolts more frequently.
3. Terminus: A defensive item that gives a shield when Vayne's health drops low, perfect for surviving in extended teamfights.

Build 2: Blade of The Ruined King + Guinsoo's Rageblade + Wit's End

This second build offers a balance of offense and defense with a win rate of 58.86% across 5,598 games. It's ideal for games against heavy magic damage teams.

1. Blade of The Ruined King
2. Guinsoo's Rageblade
3. Wit's End: Grants magic resist, attack speed, and healing on hit, perfect for facing strong AP champions.

Vayne Runes

For runes, the Precision tree is ideal, offering increased attack speed, damage, and survivability. The most frequently used rune setup for Vayne is as follows:

Primary Path: Precision

1. Lethal Tempo: Increases Vayne’s attack speed after attacking an enemy, enabling her to shred through opponents faster with Silver Bolts.
2. Triumph: Restores health on takedown, allowing Vayne to stay in teamfights longer.
3. Legend: Alacrity: Provides bonus attack speed, which is essential for Vayne’s sustained damage output.
4. Coup de Grace: Increases damage to low-health enemies, helping Vayne secure kills in fights.

Secondary Path: Resolve

1. Conditioning: Grants bonus armor and magic resist after 12 minutes, making Vayne more durable in teamfights.
2. Overgrowth: Increases Vayne’s maximum health over time, giving her more survivability during the late game.

Vayne Top Build

Though Vayne is primarily played as an ADC, she can also be a strong pick in the top lane. The top build is similar to her ADC setup, with a focus on attack speed and true damage. Blade of The Ruined King and Guinsoo's Rageblade remain core items, and Wit's End is often picked to counter AP-heavy top laners.

In Vayne top runes, Lethal Tempo and Conditioning are also preferred for the extra attack speed and durability, helping her outlast bruisers and tanks in extended fights.

Vayne Masteries and Skill Order

To fully maximize Vayne’s potential, the following skill order is recommended: Max Q – Tumble first for mobility and damage, followed by W – Silver Bolts for enhanced true damage, and E – Condemn last for utility. Proper use of masteries ensures she reaches her full late-game potential.

Vayne Mid

While not as common, Vayne mid can be a viable option against certain AP matchups. The build for mid follows the same principles as her ADC build, with an emphasis on attack speed and true damage. Blade of The Ruined King and Guinsoo's Rageblade remain core, while Wit's End can be added to counter AP champions.

Vayne Win Rate and Strategy

In Season 14, Vayne's win rate has consistently been strong, particularly when utilizing the builds and runes outlined in this guide. Her ability to carry in the late game and deal significant true damage makes her a high-priority pick. However, Vayne's early game is weaker, so positioning and farming safely during this phase is crucial.

Vayne is a late-game hyper-carry who thrives on dealing true damage and shredding tanks. With the right LoL Vayne build, runes, and strategies, you can maximize her potential and dominate in Season 14. Whether you’re playing Vayne ADC, experimenting with a top build, or trying her in the mid lane, the correct setup will ensure she has the tools to carry your team to victory and our guide is here to provide you with the best Vayne build and more.